Technologies de l’Information pour la Santé

24h15

To introduce surface plasmons and localized plasmons. To present plasmon excitation techniques with application to SPR biochips and antibody/antigen kinetics.

• Historical background. Optics of metals. Drude model. Intraband/interband transition. Validity of Drude model. Brendel-Bormann model. Metal interfaces. Evanescent waves. Surface plasmons. Excitation/Resonance. Otto experiment. Kretschmann-Raether experiment. Other excitation techniques. Labelless biochips. SPR biochips. Surface functionalization. Langmuir model. Antibody/antigen kinetics. Sensograms. Biochip performances. Electrospotting. SPRi.

• Practical works (4 hours): Numerical simulation and study of a time-resolved SPR with a FEM software (COMSOL)
• Project (12 hours): design and construction of an SPR chip microfluidic cavity, characterization and observation of kinetic antibodies / antigens by optical imaging.

• To understand principles of surface plasmon and localized plasmon resonances.
• To be able to use and design SPR biochips under specifications compatible with health IT.

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